Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

CM Phelan; KB Kuchenbaecker; JP Tyrer; SP Kar; K Lawrenson; SJ Winham; J Dennis; A Pirie; MJ Riggan; G Chornokur; MA Earp; PC Lyra; JM Lee; S Coetzee; J Beesley; L McGuffog; P Soucy; E Dicks; A Lee; D Barrowdale; J Lecarpentier; G Leslie; CM Aalfs; KKH Aben; M Adams; J Adlard; IL Andrulis; H Anton-Culver; N Antonenkova; G Aravantinos; N Arnold; BK Arun; B Arver; J Azzollini; J Balmaña; SN Banerjee; L Barjhoux; RB Barkardottir; Y Bean; MW Beckmann; A Beeghly-Fadiel; J Benitez; M Bermisheva; MQ Bernardini; MJ Birrer; L Bjorge; A Black; K Blankstein; MJ Blok; C Bodelon; N Bogdanova; A Bojesen; B Bonanni; Å Borg; AR Bradbury; JD Brenton; C Brewer; L Brinton; P Broberg; A Brooks-Wilson; F Bruinsma; J Brunet; B Buecher; R Butzow; SS Buys; T Caldes; MA Caligo; I Campbell; R Cannioto; ME Carney; T Cescon; SB Chan; J Chang-Claude; S Chanock; XQ Chen; YE Chiew; J Chiquette; WK Chung; KBM Claes; T Conner; LS Cook; J Cook; DW Cramer; JM Cunningham; AA D'Aloisio; MB Daly; F Damiola; DD Sakaeva; A Dansonka-Mieszkowska; F Dao; R Davidson; A DeFazio; C Delnatte; KF Doheny; O Diez; YC Ding; JA Doherty; SM Domchek; CM Dorfling; T Dörk

Journal article

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

CM Phelan, KB Kuchenbaecker, JP Tyrer, SP Kar, K Lawrenson, SJ Winham, J Dennis, A Pirie, MJ Riggan, G Chornokur, MA Earp, PC Lyra, JM Lee, S Coetzee, J Beesley, L McGuffog, P Soucy, E Dicks, A Lee, D Barrowdale Show all

Nature Genetics | Published : 2017

DOI: 10.1038/ng.3826

Abstract

To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility l..

View full abstract

University of Melbourne Researchers

Fiona Bruinsma Author

Ian Campbell Author

Graham Giles Author

Kelly Phillips Author

Related Projects (1)

REDUCING THE BURDEN OF BREAST CANCER FOR AUSTRALIAN WOMEN AND THEIR FAMILIES

Grants

Awarded by Government of Canada

Funding Acknowledgements

The OCAC OncoArray genotyping project was funded through grants from the US National Institutes of Health (CA1X01HG007491-01 (C.I.A.), U19-CA148112 (T.A.S.), R01-CA149429 (C.M.P.) and R01-CA058598 (M.T.G.)); Canadian Institutes of Health Research (MOP-86727 (L.E.K.)); and the Ovarian Cancer Research Fund (A.B.). Funding for the CIMBA OncoArray genotyping was provided by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the Ministere de l'Economie, de la Science et de l'Innovation du Quebec through Genome Quebec, the Quebec Breast Cancer Foundation for the PERSPECTIVE project, the US National Institutes of Health (CA1X01HG007491-01 (C.I.A.)), the Odense University Hospital Research Foundation (M.T.), the National R&D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea (1420190 (S.K.P.)), the Italian Association for Cancer Research (IG16933 (L.O.)) and German Cancer Aid (110837 (R.K.S.). Funding sources for the contributing studies are provided in the Supplementary Note.